HPV Global Facts
As the incidence of oropharyngeal cancer rise by one third in the last decade (13), it became clear that HPV screening is a very essential action while the smoking and drinking are not the only causative reasons for that type of cancer.
Almost 70% of oropharyngeal cancer tend to be HPV-mediated because the oropharynx is susceptible to HPV infection (2, 10, 14), while up to 25% of all the head and neck cancers diagnosed in US are tobacco independent (4). The average age of diagnosis in men is around 40-50 (3), while there is tendency of cancer incidences in younger ages. 7% of the population between the ages of 14 and 69 are HPV infected in oral cavity at any given time (6, 7). The men are more vulnerable compare to women to that type of cancer, with a ratio of 3:1 (5).
Furthermore, there are differences in incidence of lip and oral cavity cancers between European countries where Spain and Hungary have the majority of incidences and there are evidences for a continue increasing rate in several Eastern European member states (11, 12).
In US there is an estimation that by the year 2020 the HPV mediated oropharyngeal cancer cases will be outnumber of HPV mediated cervix cancer cases (1)
Identality provide a non-invasive HPV detection and typing screening test from mouthwash sample. The test reports a dual result by detecting and typing the HPV.
It is well known that the HPV 16 type is the most frequent type related to mouth cancer by increasing the susceptibility by 15- to 210-fold risk for oropharyngeal cancer (8, 14, 15).
However, is not the only one and it is important to be determined which other subtypes of HPV are responsible for mouth cancer, while there are not modified recommendation based on HPV status to date for surveillance (10).
By taking in account that early detection for mouth cancer results in a survival outcome of 90% (13), HPV screening is highly essential before the formation of a tumor mass by giving to the people the opportunity for prevention of cancer formation and opportunity for early HPV vaccination before starting of an active sexual life, and to the dentist the opportunity to become the prevention gatekeeper of oral cancer.
The criteria for someone to be tested are:
1. People who are sexually active
2. People with oral cancer risk factors
3. People having signs and symptoms of oral cancer
4. Patients having suspicious oral lesions