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HPV Global Facts

 

As the incidence of oropharyngeal cancer rise by one third in the last decade (13), it became clear that HPV screening is a very essential action while the smoking and drinking are not the only causative reasons for that type of cancer.
Almost 70% of oropharyngeal cancer tend to be HPV-mediated because the oropharynx is susceptible to HPV infection (2, 10, 14), while up to 25% of all the head and neck cancers diagnosed in US are tobacco independent (4). The average age of diagnosis in men is around 40-50 (3), while there is tendency of cancer incidences in younger ages. 7% of the population between the ages of 14 and 69 are HPV infected in oral cavity at any given time (6, 7). The men are more vulnerable compare to women to that type of cancer, with a ratio of 3:1 (5).
Furthermore, there are differences in incidence of lip and oral cavity cancers between European countries where Spain and Hungary have the majority of incidences and there are evidences for a continue increasing rate in several Eastern European member states (11, 12).
In US there is an estimation that by the year 2020 the HPV mediated oropharyngeal cancer cases will be outnumber of HPV mediated cervix cancer cases (1)

 

Testing Offer
Identality provide a non-invasive HPV detection and typing screening test from mouthwash sample. The test reports a dual result by detecting and typing the HPV.
It is well known that the HPV 16 type is the most frequent type related to mouth cancer by increasing the susceptibility by 15- to 210-fold risk for oropharyngeal cancer (8, 14, 15).
However, is not the only one and it is important to be determined which other subtypes of HPV are responsible for mouth cancer, while there are not modified recommendation based on HPV status to date for surveillance (10).

 

Testing Value
By taking in account that early detection for mouth cancer results in a survival outcome of 90% (13), HPV screening is highly essential before the formation of a tumor mass by giving to the people the opportunity for prevention of cancer formation and opportunity for early HPV vaccination before starting of an active sexual life, and to the dentist the opportunity to become the prevention gatekeeper of oral cancer.

 

Test Criteria
The criteria for someone to be tested are:
1. People who are sexually active
2. People with oral cancer risk factors
3. People having signs and symptoms of oral cancer
4. Patients having suspicious oral lesions

Almost 70% of Oropharyngeal cancers related to HPV infection. 25% of all the head and neck cancers diagnosed in US are tobacco independent.

The men are more vulnerable compare to women to HPV mediated oropharyngeal cancer, with a ratio of 3:1

7% of the population between the ages of 14 and 69 are HPV infected in oral cavity at any given time.

The average age of diagnosis in men is around 40-50 (3), while there is tendency of cancer incidences in younger ages

European countries differences in estimated cancer incidences

Male -female differences in estimated cancer incidences

An Oral Cancer Screening test may just save your life!

References
1. Chaturvedi AK et al 2011 Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol;29:4294-301
2. Mehanna H et al 2013 Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer – systematic review and meta-analysis of trends by time and region. Head Neck;35:747-55
3. Chaturvedi AK et al 2008 Incidence trends for human papillomavirus – related and unrelated oral squamous cell carcinomas in the United States. J Clin Oncol;26:612-9
4. De Martel C et al 2012 Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol;13:607-15
5. Gillison ML et al 2008 Distinct risk factors profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst;100:407-20
6. Cates W Jr 1999 Estimates of incidence and prevalence of sexually transmitted diseases in the United States.American Social Health Association Panel. Sex Transm Dis;26:S2-7
7. Gillison ML et al 2009-2010 Prevalence of oral HPV infection in the United States.JAMA;307:693-703
8. Hansson BG et al 2005 Strong association between infection with human papillomavirus and oral and oropharyngeal squamous cell carcinoma: a population-based case-control study in southern Sweden. Acta Otolaryngol;125:1337-44
9. D’Souza G et al 2014 Oral human papillomavirus (HPV) infection in HPV-positive patients with oropharyngeal cancer and their partners. J Clin Oncol;32:2408-15
10. Lewis A et al 2015 The New Face of Head and Neck Cancer: The HPV Epidemic. Oncology;29(9):616-26.
11. www.oralhealthplatform.eu
12. http://globocan.iarc.fr/
13. www.mouthcancer.org
14. www.cdc.gov/cancer/hpv/statistics

 

 

For more information download Oral Hpv presentation by Identality.